As it is known important restrictive factor in the suitable
pharmaceutical treatment constitute the side effects of medicine, what often
they constitute also reason of interruption of treatment. In the case where one
patient needs two or more medicines then thesituation is complicated not only
by the likely combination of sideeffects but also by the likely interaction of
granted medicines. Today that the medium time of life has been increased, has
been increased also the number of individuals that suffers from one or
more aged deseases as hypertension, cardiopathies,
pneymonopa'cejes, etc. for that it should it takes chronically
medicines. In this patients often it happens and from some otherdesease
acute, as infections, allergies, vertigo k.a, that need additional
pharmaceutical education, or they suffer certain chirurgical intervention where
are requiredalso additional medicines (antibiotics, anaesthetics, tranquilizing
k.l.p.). In all these the cases it is possible or are intensified the
sideeffects of medicines because inadequate combination, or is influenced the
result (aid or reduction of sought result) orresults damage of certain bodies
or even exists leathal conclusion. The medicines however allilepjdroy'n
only between them but also withthe food, who can influence not only the
absorption of medicine but also hismetabolism with result frequent the
insufficient treatment or even thevery increased levels of granted medicine
(poisoning). Most interactions of medicines have unfavourable results. The 7%
of roughly undesirable energies are owed in the interactions ofmedicines of
Roughly 4% of all deaths are owed in side effects (the1-1,5% because
interaction of medicines). From more it is obvious that the interactions of
medicines are perhapsmore frequent than that it is considered by a lot of
doctors and oftenconstituting important clinical problem of that the
repercussionsmainly in the patient, but in the economy it can also they are
serious. Because it is impossible remembers somebody all the likelyinteractions
two and often more medicines, the doctor or the pharmacist will be supposed to
find itself invigilance for likely unfavourable interactions, when they decide
the issuing of some medicine.
The
effects of pharmaceutical interactions are more often than not unwanted and
harmful. Types of such interactions include duplication, opposition
(antagonism), and alteration of what the body does to one or both medicines.
Duplication occurs when more than one pharmaceuticals with the same effect are
taken (either inadvertently by the individual or prescribed by one or more
professionals), resulting in the possible intensification of their therapeutic
effects and their side effects. Opposition
takes place when two or more medicines with opposing actions can interact,
thereby reducing the effectiveness of one or both. Alteration happens when one
pharmaceutical alters the way the body absorbs, distributes, metabolises, or
excretes other pharmaceuticals. Moreover, it is important to stress the fact
that pharmaceuticals do not only interact with other pharmaceuticals but also
with food, alcohol, herbs, etc, a situation which can affect not only the
absorption of medication, but also its metabolism resulting in inefficient
treatment or in high levels of the provided drug (e.g. poisoning).
The
above effects can cause various levels of complications to an individual’s
health, such as drowsiness, slowed reactions, stomach upset,
dizziness, light-headedness, irregular heartbeat, sudden rise in blood
pressure, organ damage, or even patient death. When such cases arise, they
involve significant medical, social, ethical and financial issues (liabilities,
quality of healthcare provision, treatment efficacy, quality of life etc) to
all relevant stakeholders (healthcare professionals and organisations,
insurance companies, pharmaceutical companies, government, etc).
Statistics
indicate that the majority of pharmaceutical interactions have unfavourable
results and that about 7% of the side effects caused by prescribed medication
are due to drug interactions. Furthermore, about 4% of the deaths are due to
side effects (1-1,5% because of drug interactions).